Lipids and Lipid Derivatives
Medchemexpress LLC AKN-028 acetate | 98.38% | 362.39 | 1 ML
AKN-028 acetate is a novel, potent, and orally active tyrosine kinase (TK) inhibitor. It specifically targets FMS-like receptor tyrosine kinase 3 (FLT3) with an IC50 value of 6 nM. This compound inhibits FLT3 autophosphorylation and induces a dose-dependent cytotoxic response. It also induces apoptosis through the activation of caspase 3, making it suitable for research in acute myeloid leukemia (AML).
- Potent and orally active tyrosine kinase inhibitor.
- Targets FLT3 with high specificity (IC50 = 6 nM).
- Induces dose-dependent cytotoxic response.
- Activates caspase 3, leading to apoptosis.
- Useful for acute myeloid leukemia (AML) research.
Medchemexpress LLC PRT062607 (acetate) | 1370261-98-5 | C21H27N9O3 | 1 ML
PRT062607 (acetate) is a laboratory chemical identified by CAS number 1370261-98-5 and chemical formula C21H27N9O3. It is stable under recommended storage conditions and intended for research use.
- Solid appearance
- Stable under recommended storage conditions
- Recommended storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months; -20°C for 1 month (sealed, away from moisture)
- Can be shipped at room temperature if less than 2 weeks
- Also known as P505-15 (acetate), PRT-2607 (acetate), and BIIB-057 (acetate)
Medchemexpress LLC Alisol B 23-acetate | 26575-95-1 | 514.74 | 50 MG
Alisol B 23-acetate | 26575-95-1 | 514.74 | 50 MG
Medchemexpress LLC Atosiban (acetate) | 914453-95-5 | 99.8% | 1054.24 | 50 MG
Atosiban acetate is a nonapeptide competitive vasopressin/oxytocin receptor antagonist and a desamino-oxytocin analogue. It is the main tocolytic agent and has the potential for research into spontaneous preterm labor.
- Competitive vasopressin/oxytocin receptor antagonist and desamino-oxytocin analogue
- Functions as the main tocolytic agent
- Suitable for research into spontaneous preterm labor
- Inhibits oxytocin-mediated IP3 release from myometrial cells
- Reduces intracellular calcium release and influx
- Suppresses oxytocin-mediated prostaglandin release
- Influences feto-maternal cardiovascular and renal systems
- Blocks oxytocin-receptor-expressing neuron activation
Apexbio Technology LLC CEFPODOXIME-D3-1MG
Cefpodoxime-d3 (CAS No 2477791-28-7) is a deuterated version of the third-generation cephalosporin antibiotic cefpodoxime used primarily in biomedical research to study its pharmacokinetics and metabolic pathways Originating from modifications of the standard cefpodoxime molecule it retains similar antibacterial activity by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins effectively disrupting cell wall biosynthesis Typically exhibiting in vitro activity in the nanomolar to low micromolar range it is employed in various experimental setups including cell models and animal studies to investigate its efficacy and safety profile This compound is also pertinent in drug screening scenarios where detailed metabolic and pharmacokinetic data are required Experimental concentrations typically depend on the specific research design allowing flexibility for various investigative frameworks
Medchemexpress LLC N-(1-phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine | 662164-09-2 | MFCD04077665 | 99.5% | 333.43 | C20H23N5 | 10MM 1ML
D3-βArr is a small-molecule positive allosteric modulator of the thyrotropin receptor intended for research use. It is supplied as a solid and as a 10 mM solution in DMSO, and is used in receptor pharmacology and functional assays to study β-arrestin translocation and TSHR signaling.
- Positive allosteric modulator of the thyrotropin receptor (TSHR).
- Supports beta-arrestin translocation and TSHR functional assays.
- High purity (reported ~99.5%).
- Available as solid (multiple mg sizes) and 10 mM solution in DMSO.
- Molecular formula C20H23N5, molecular weight 333.43.
Sigma Aldrich Fine Chemicals Biosciences 2 Keto 3 methyl d3 butyrc500MG
2 Keto 3 methyl d3 butyrc500MG
Medchemexpress LLC Ibuprofen-d3 | 121662-14-4 | 99.94% | C13H15D3O2 | 50 MG
Ibuprofen-d3 is a deuterium labeled Ibuprofen, acting as a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM. It incorporates stable heavy isotopes, such as deuterium, into drug molecules as tracers for quantitation during drug development. This process has the potential to affect pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Dopamine D2 receptor antagonist-1 | 1055411-77-2 | 99.1% | 1 ML
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity.
- Acts as a negative allosteric modulator
- Targets the dopamine D2 receptor (D2R)
- Exhibits sub-mM affinity
Cambridge Isotope Laboratories 2 4-Dinitrotoluene (ring-D3 98%) 1 mg/mL in acetonitrile-D3 1 mL
2 4-Dinitrotoluene (ring-D3 98%) 1 mg/mL in acetonitrile-D3 1 mL
Cayman Chemical 6-MethylmercaptopurIn-d3 25mg
An internal standard for the quantification of 6-MMP by GC- or LC-MS
Medchemexpress LLC Sulfadoxine-d3 | 1262770-70-6 | MFCD10567357 | 98.0% | 313.35 | C12H11D3N4O4S | 10 MG
Sulfadoxine-d3 is the deuterium-labeled isotopologue of sulfadoxine, a long-acting sulfonamide anti-malarial agent provided as a high-purity analytical standard for research. It is used as an internal standard, tracer, or reference material in pharmacokinetic and mass spectrometry studies.
- Deuterium-labeled analog for tracer and internal standard use.
- High purity, 98.0%, suitable for analytical applications.
- Soluble in DMSO, limited solubility in water.
- Stable as a powder when stored at -20°C, with defined in-solution storage limits.
- Supplied in small analytical quantities useful for method development and validation.
Medchemexpress LLC D3/5-HT receptor modulator-1 | 898532-85-9 | 391.51 | 1 ML
D3/5-HT receptor modulator-1 (compound 5i) is a selective dopamine D3 receptor and 5-HT2A receptor antagonist and a partial 5-HT1A receptor agonist. It has a low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels, and presents an atypical antipsychotic profile.
- Selective dopamine D3 receptor and 5-HT2A receptor antagonist.
- Partial 5-HT1A receptor agonist.
- Shows Ki values of 4.5 nM (D3), 11.9 nM (5-HT2A), and 15.3 nM (5-HT2A).
- Low affinity for dopamine D2 receptors, 5-HT2C receptors, and hERG channels.
- Atypical antipsychotic profile.
Sigma Aldrich Fine Chemicals Biosciences Methyl-d3-amine hydrochlor1G
methyl Methyl-d3-amine hydrochlor1G
Cayman Chemical 25-hydroxy VItamIn D2 1mg
A metabolite of vitamin D2; serum levels of 25-hydroxy vitamin D2 have been used as a marker of vitamin D status